Top 21 papilloma virus and p53 tuyệt nhất 2022

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Tóm tắt: khủng long Human papillomavirus (HPV) DNA replication can be inhibited by the cellular tumour suppressor protein p53. However, the mechanism through which p53 inhibits viral replication and the role that this might play in the HPV life cycle are not known. The papillomavirus …

Khớp với kết quả khủng long tìm kiếm: …

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Tóm tắt: khủng long Papillomavirus and p53

Khớp với kết quả khủng long tìm kiếm: Papillomavirus and p53 H zur Hausen. Nature. 1998. Show details Nature Actions. Search in PubMed Search in NLM Catalog … The prevalence of human papilloma virus in esophageal squamous cell carcinoma. Noori S, Monabati A, Ghaderi A. Noori S, et al. Iran J Med Sci. 2012 Jun;37(2):126-33. Iran J Med Sci. 2012. PMID: 23115442 Free PMC article. Detection of human ……

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Tóm tắt: khủng long Certain types of human papillomavirus (HPV) are involved in the development of cervical and other perianal cancers, and a new study takes us a step closer to working out how. An HPV-encoded oncoprotein known as E6 can interact with the human tumour suppressor p53, inactivating it and preventing it from carrying out its normal functions. The authors have found that people can carry either an arginine or a proline residue at a specific position in p53, and that E6 binds best to the arginine form. What’s more, they’ve found that people with two copies of the p53 gene that specifies the arginine residue have a seven-fold higher risk of developing cervical cancer than those without.

Khớp với kết quả khủng long tìm kiếm: 21.05.1998 · Residual p53 activity has been shown in some cervical carcinoma cell lines that contain HPV, and it would be interesting to see whether these lines contain the arginine or the proline form of p53…….

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Ngày đăng khủng long : 24/8/2021

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Tóm tắt: khủng long We could not show any statistical association between abnormal p53 gene-product expression by immunohistochemistry in conjunctival squamous cell carcinomas and HPV infection by PCR detection techniques.

Khớp với kết quả khủng long tìm kiếm: The relationship between human papillomavirus and p53 gene in conjunctival squamous cell carcinoma Abstract Purpose: The p53 tumor-suppressor gene has been documented to exist in mutated forms in many types of squamous cell carcinoma in the body….

Tác giả: khủng long pubmed.ncbi.nlm.nih.gov

Ngày đăng khủng long : 2/5/2021

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Tóm tắt: khủng long Recent studies have shown that p53 mutations are frequently found in cancer of the head and neck, whereas others have indicated that human papilloma virus (HPV) infection may be involved. Thus far, no studies have examined both p53 and HPV in the same patient population and correlated the results wi …

Khớp với kết quả khủng long tìm kiếm: Recent studies have shown that p53 mutations are frequently found in cancer of the head and neck, whereas others have indicated that human papilloma virus (HPV) infection may be involved. Thus far, no studies have examined both p53 and HPV in the same patient population and correlated the results with clinical characteristics and outcome….

Tác giả: khủng long pubmed.ncbi.nlm.nih.gov

Ngày đăng khủng long : 12/7/2021

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Tóm tắt: khủng long The data of this pilot study show the suggestion of a positive trend in the correlation between tumour grade/stage and high-risk type HPV infection. However, no additional risk for progression is found for p53 wild-type patients with a high-risk HPV infection.

Khớp với kết quả khủng long tìm kiếm: Objectives: High-risk human papilloma virus (HPV) types stimulate degradation and deactivation of protein associated with the p53 tumour suppressor gene via the ubiquitin-dependent pathway. For a long time, changes of the p53 tumour suppressor gene have been correlated with poor clinical outcome in patients with superficial bladder cancer….

Tác giả: khủng long www.ncbi.nlm.nih.gov

Ngày đăng khủng long : 28/8/2021

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Tóm tắt: khủng long Papillomavirus and p53

Khớp với kết quả khủng long tìm kiếm: 21.05.1998 · 1. Nature. 1998 May 21;393(6682):217. Papillomavirus and p53. zur Hausen H. Comment on Nature. 1998 May 21;393(6682):229-34. PMID: 9607756…

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Ngày đăng khủng long : 17/4/2021

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Tóm tắt: khủng long It is proposed that genetic and epigenetic alteration of p53 follow distinct pathways during the development of HNSCC from normal epithelium via dysplasia. The p53 mutation and HPV mediated p53 inactivation possibly constitute two independent pathways of tumourigenesis.

Khớp với kết quả khủng long tìm kiếm: Results: HPV positivity in the HNSCC samples was 69%; 21% of the HNSCC were found to harbour p53 mutations in the coding region of the gene. The absence of the p53 mutation in HPV positive tumours was statistically significant compared to the HPV negative tumours (p = 0.01), but the same did not hold true for p53 LOH (p = 1.0)….

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Ngày đăng khủng long : 24/6/2021

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Tóm tắt: khủng long An inverse relation between HPV and p53 overexpression in sinonasal carcinomas associated with inverted papillomas appears to have been demonstrated. HPV and p53 might also have an etiological role among the carcinomas associated with exophytic papillomas.

Khớp với kết quả khủng long tìm kiếm: Objectives: To determine a putative role and relation between human papilloma virus (HPV) and p53 in the etiology of sinonasal carcinomas associated with papillomas. Study design: The study group consists of all patients with sinonasal carcinomas associated with papillomas diagnosed in Denmark from 1980 to 1998. After reviewing our national pathological files, tumor tissues from 36 patients ……

Tác giả: khủng long aacrjournals.org

Ngày đăng khủng long : 6/3/2021

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Tóm tắt: khủng long Abstract. Recent studies have shown that p53 mutations are frequently found in cancer of the head and neck, whereas others have indicated that human papilloma virus (HPV) infection may be involved. Thus far, no studies have examined both p53 and HPV in the same patient population and correlated the results with clinical characteristics and outcome. The purpose of this study was to examine any interrelationship between p53 and HPV in patients with squamous cell carcinoma (SCC) of the head and neck. We also planned to correlate the experimental findings with clinical characteristics, known risk factors, and treatment outcome to determine whether any prognostic factors could be detected. Archival material from 66 patients with SCC of the head and neck were selected for study based on the availability of tissue from the primary tumors prior to treatment. A data base was constructed containing all clinical parameters at the time of diagnosis and risk factors. Genomic DNA was isolated and amplified using PCR, followed by SSCP analysis and direct genomic sequencing of all variants to detect p53 mutations. Two independent methods were used for HPV detection: (a) PCR amplification using primers homologous to the E6 region of HPV 16, 18, and 33, followed by RFLP analysis; and (b) PCR amplification with HPV L1 consensus primers, followed by triple restriction enzyme digestion. The results were entered into the data base for statistical analysis. Twenty-four percent of patients were found to have p53 mutations, and 18% were positive for HPV infection. Only one patient was positive for both. Tonsilar cancer was strongly correlated with HPV (P = 0.0001) and inversely correlated with p53 (P = 0.03). The only clinical parameter associated with p53 mutation was a trend toward a heavier smoking history. A subset analysis of the patients with tonsilar cancer revealed inverse correlations with smoking (P = 0. 015) and alcohol use (P = 0.05). Also, white patients with SCC of the tonsil were more likely to be HPV positive (P = 0.015). No significant relationships with outcome were detected with either p53 or HPV in the entire population. A subset analysis of patients with stage IV disease revealed that HPV infection was correlated with overall survival. This is the largest study to date to examine both p53 and HPV in patients with SCC of the head and neck. Our results suggest that HPV may be involved in the development of these cancers in patients without traditional risk factors and that HPV-related cancers are more prevalent in the white race.

Khớp với kết quả khủng long tìm kiếm: 01.04.1996 · Abstract Recent studies have shown that p53 mutations are frequently found in cancer of the head and neck, whereas others have indicated that human papilloma virus (HPV) infection may be involved. Thus far, no studies have examined both p53 and HPV in the same patient population and correlated the results with clinical characteristics and outcome….

Tác giả: khủng long www.researchgate.net

Ngày đăng khủng long : 28/1/2021

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Tóm tắt: khủng long Bài viết về (PDF) Human papilloma virus and p53 in Head and Neck …. Đang cập nhật…

Khớp với kết quả khủng long tìm kiếm: Recent studies have shown that p53 mutations are frequently found in cancer of the head and neck, whereas others have indicated that human papilloma ……

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Ngày đăng khủng long : 6/7/2021

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Tóm tắt: khủng long We aimed to reveal the prevalence and pattern of human papillomavirus (HPV) infection and p53 mutations among Japanese head and neck squamous cell carcinoma (HNSCC) patients in relation to clinicopathological parameters. Human papillomavirus DNA and p53 …

Khớp với kết quả khủng long tìm kiếm: 30.03.2014 · We aimed to reveal the prevalence and pattern of human papillomavirus (HPV) infection and p53mutations among Japanese head and neck squamous cell carcinoma (HNSCC) patients in relation to clinicopathological parameters. Human papillomavirus DNA and p53mutations were examined in 493 HNSCCs and its subset of 283 HNSCCs….

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Ngày đăng khủng long : 27/4/2021

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Tóm tắt: khủng long Human papillomavirus (HPV) DNA replication can be inhibited by the cellular tumour suppressor protein p53. However, the mechanism through which p53 inhibits viral replication and the role that this might play in the HPV life cycle are not known. The papillomavirus …

Khớp với kết quả khủng long tìm kiếm: Human papillomavirus (HPV) DNA replication can be inhibited by the cellular tumour suppressor protein p53. However, the mechanism through which p53 inhibits viral replication and the role that this might play in the HPV life cycle are not known….

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Ngày đăng khủng long : 16/3/2021

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Tóm tắt: khủng long These data suggest that HPV16/18 infection and/or p53 alterations are associated with oral squamous cell carcinoma. No inverse correlation exists between oncogenic HPV infection and p53 alteration.

Khớp với kết quả khủng long tìm kiếm: Objective: The aim of this study was to examine human papillomavirus 16/18 infection incidence and p53 alteration in oral squamous cell carcinoma and to determine whether a correlation existed between HPV infection incidence and p53 alteration in this disease. Methods: A series of 60 oral tissues (40 oral squamous cell carcinomas, 20 normal oral mucosas) was studied by polymerase ……

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Ngày đăng khủng long : 16/3/2021

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Tóm tắt: khủng long P16 and p53 protein expression, and high-risk human papillomavirus (HPV-HR) types have been associated with survival in head and neck cancer (HNC). Evidence suggests that multiple molecular pathways need to be targeted to improve the poor prognosis of …

Khớp với kết quả khủng long tìm kiếm: 11.02.2010 · P16 and p53 protein expression, and high-risk human papillomavirus (HPV-HR) types have been associated with survival in head and neck cancer (HNC). Evidence suggests that multiple molecular pathways need to be targeted to improve the poor prognosis of HNC….

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Ngày đăng khủng long : 15/5/2021

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Tóm tắt: khủng long The aim of the current study was to compare the role of p53 and human papillomavirus (HPV) in schistosomiasis-related and schistosomiasis-unrelated carcinoma of the urinary bladder. To achieve this aim, we investigated 114 bladder carcinomas for p53 oncoprotein expression by immunohistochemistry and for human papillomavirus by in situ hybridization technique. The results revealed that 64 tumors (56.1%) were schistosomiasis-associated. Sixty seven (58.8%) were transitional cell carcinomas and 32 (28%) were squamous cell carcinomas. The remaining 15 tumors (13.2%) included adenocarcinomas and sarcomatoid carcinomas. In both schistosomiasis-associated and non-associated carcinomas, p53 oncoprotein expression was significantly higher in poorly differentiated tumors. However, it was significantly higher in locally more invasive tumors in the schistosomal carcinomas only. HPV types 16/18 could be detected in 1 of the 114 bladder carcinomas (0.95%), which was schistosomiasis-related squamous cell carcinoma in situ. These results suggest that p53 immunohistochemistry can be a prognostic factor in both schistosomal and nonschistosomal bladder cancer. More importantly, HPV does not seem to play a role in the pathogenesis of either type of bladder cancer in our country.(Pathology Oncology Research Vol 12, No 3, 173–178)

Khớp với kết quả khủng long tìm kiếm: 01.12.2006 · To achieve this aim, we investigated 114 bladder carcinomas for p53 oncoprotein expression by immunohistochemistry and for human papillomavirus by in situ hybridization technique. The results revealed that 64 tumors (56.1%) were schistosomiasis-associated….

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Ngày đăng khủng long : 15/3/2021

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Tóm tắt: khủng long High-risk human papilloma virus (HPV) types stimulate degradation and deactivation of protein associated with the p53 tumour suppressor gene via the u…

Khớp với kết quả khủng long tìm kiếm: 01.08.2007 · Objectives. High-risk human papilloma virus (HPV) types stimulate degradation and deactivation of protein associated with the p53 tumour suppressor gene via the ubiquitin-dependent pathway. For a long time, changes of the p53 tumour suppressor gene have been correlated with poor clinical outcome in patients with superficial bladder cancer. We aimed to ……

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Ngày đăng khủng long : 21/5/2021

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Tóm tắt: khủng long Abstract. Background: High-risk human papillomavirus (HPV-HR) is a significant risk factor for head and neck cancer (HNC), abrogating normal p53 function. In addition, HPV and p53 have been associated with prognosis of these tumors but the findings have been inconsistent. We examined p53 expression and HPV-HR individually and jointly for differences in predicting HNC survival.Methods: HNC patients (n = 294) were evaluated for p53 by immunohistochemical staining. HPV was detected by PCR/dot blot hybridization and sequencing.Results: HNC tumors showed 48% with p53 overexpression and 27% with HPV-HR. Multivariate analyses showed that p53 positivity was significantly associated with higher risk of disease-specific [hazard ratio (HR); 2.0; 95% confidence interval (95% CI), 1.1-3.7] and recurrence-free mortality (HR, 2.8; 95% CI, 1.4-5.3). HPV− cases had significantly worse disease-specific survival (HR, 2.8; 95% CI, 1.3-6.3) compared with HPV-HR cases. When analyzed jointly, with p53−/HPV-HR tumors as the reference group, p53+/HPV− patients had the worst disease-specific (HR, 5.3; 58% versus 15%, P = 0.006) and recurrence-free survival rates (HR, 9.5; 17% versus 89%, P = 0.001), in contrast to the p53−/HPV− and p53+/HPV-HR groups, which had less elevated and different risks for disease-specific survival (HR, 2.5 and 1.7, respectively) and recurrence-free survival (HR, 4.2 and 7.2, respectively).Conclusion: Joint assessment of p53/HPV status provides different HRs for each clinical outcome in the four biomarker groups that are distinct from the individual biomarkers. These findings suggest that joint assessment of p53/HPV provides a better indicator of prognosis and potentially different types of treatments. (Cancer Epidemiol Biomarkers Prev 2008;17(2):421–7)

Khớp với kết quả khủng long tìm kiếm: 11.02.2008 · Background: High-risk human papillomavirus (HPV-HR) is a significant risk factor for head and neck cancer (HNC), abrogating normal p53 function. In addition, HPV and p53 have been associated with prognosis of these tumors but the findings have been inconsistent….

Tác giả: khủng long pubmed.ncbi.nlm.nih.gov

Ngày đăng khủng long : 6/1/2021

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Tóm tắt: khủng long High risk human papilloma viruses cause several types of cancer. The HPV oncoproteins E6 and E7 are essential for oncogenic cell transformation. E6 mediates the degradation of the tumor suppressor p53, and E7 can form complexes with the retinoblastoma pRB tumor suppressor. Recently, it has been show …

Khớp với kết quả khủng long tìm kiếm: E6 mediates the degradation of the tumor suppressor p53, and E7 can form complexes with the retinoblastoma pRB tumor suppressor. Recently, it has been show … Human papilloma virus E7 oncoprotein abrogates the p53-p21-DREAM pathway Sci Rep. 2017 Jun 1;7(1):2603. doi: 10.1038/s41598-017-02831-9. Authors Martin Fischer 1 , Sigrid Uxa 2 , Clara Stanko 2 , Thomas ……