Top 21 b7-h3 a checkpoint molecule as a target for cancer immunotherapy tuyệt nhất 2022

Tác giả: khủng long pubmed.ncbi.nlm.nih.gov

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Tóm tắt: khủng long B7-H3 (also known as CD276) is a newly found molecule of B7 family, which may be a promising target for cancer treatment. B7-H3 protein was demonstrated to be expressed in several kinds of tumor tissues including non-small-cell lung cancer (NSCLC) and prostate cancer. Its expression is highly associ …

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Tóm tắt: khủng long B7-H3 (also known as CD276) is a newly found molecule of B7 family, which may be a promising target for cancer treatment. B7-H3 protein was demonstrated to be expressed in several kinds of tumor tissues including non-small-cell lung cancer (NSCLC) and …

Khớp với kết quả khủng long tìm kiếm: 25.03.2020 · B7-H3 (also known as CD276) is a newly found molecule of B7 family, which may be a promising target for cancer treatment. B7-H3 protein was demonstrated to be expressed in several kinds of tumor tissues including non-small-cell lung cancer (NSCLC) and prostate cancer. Its expression is highly associated with undesirable treatment outcomes and survival time, due to ……

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Tóm tắt: khủng long B7-H3 (also known as CD276) is a newly found molecule of B7 family, which may be a promising target for cancer treatment. B7-H3 protein was demonstrated to be expressed in several kinds of tumor tissues including non-small-cell lung cancer (NSCLC) and prostate cancer. Its expression is highly associ …

Khớp với kết quả khủng long tìm kiếm: B7-H3 (also known as CD276) is a newly found molecule of B7 family, which may be a promising target for cancer treatment. B7-H3 protein was demonstrated to be expressed in several kinds of tumor tissues including non-small-cell lung cancer (NSCLC) and prostate cancer. Its expression is highly associated with undesirable treatment outcomes and survival time, due to function of the ……

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Tóm tắt: khủng long Bài viết về B7-H3, a checkpoint molecule, as a target for cancer …. Đang cập nhật…

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Tác giả: khủng long www.researchgate.net

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Tóm tắt: khủng long Bài viết về (PDF) B7-H3, a checkpoint molecule, as a target for cancer …. Đang cập nhật…

Khớp với kết quả khủng long tìm kiếm: B7- H3 (also known as CD276) is a newly found molecule of B7 family, which may be a promising target for cancer treatment. B7-H3 protein was demonstrated to be expressed in ……

Tác giả: khủng long www.semanticscholar.org

Ngày đăng khủng long : 28/5/2021

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Tóm tắt: khủng long A comprehensive, up-to-date summary of the advances in B7-H3 targeting approaches in cancer therapy offers a new therapeutic target with increased efficacy and less toxicity in future cancer treatment. B7-H3 (also known as CD276) is a newly found molecule of B7 family, which may be a promising target for cancer treatment. B7-H3 protein was demonstrated to be expressed in several kinds of tumor tissues including non-small-cell lung cancer (NSCLC) and prostate cancer. Its expression is highly associated with undesirable treatment outcomes and survival time, due to function of the immune checkpoint molecule. It was classified as either a co-stimulatory molecule for T cell activation or the nonimmunological role of regulating signaling pathways. Although there is still no agreed conclusion on the function of B7-H3, it may be a valuable target for cancer therapy. This review aims to provide a comprehensive, up-to-date summary of the advances in B7-H3 targeting approaches in cancer therapy. Although several challenges remain, B7-H3 offers a new therapeutic target with increased efficacy and less toxicity in future cancer treatment.

Khớp với kết quả khủng long tìm kiếm: A comprehensive, up-to-date summary of the advances in B7-H3 targeting approaches in cancer therapy offers a new therapeutic target with increased efficacy and less toxicity in future cancer treatment. B7-H3 (also known as CD276) is a newly found molecule of B7 family, which may be a promising target for cancer treatment. B7-H3 protein was demonstrated to be expressed in ……

Tác giả: khủng long www.pubpharm.de

Ngày đăng khủng long : 9/7/2021

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Tóm tắt: khủng long Bài viết về B7-H3, a checkpoint molecule, as a target for cancer immunotherapy. Đang cập nhật…

Khớp với kết quả khủng long tìm kiếm: B7-H3 (also known as CD276) is a newly found molecule of B7 family, which may be a promising target for cancer treatment. B7-H3 protein was demonstrated to be expressed in several kinds of tumor tissues including non-small-cell lung cancer (NSCLC) and prostate cancer. Its expression is highly associated with undesirable treatment outcomes and survival time, due to function of the ……

Tác giả: khủng long sci-hub.se

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Tóm tắt: khủng long Bài viết về Sci-Hub | B7-H3, a checkpoint molecule, as a target for cancer …. Đang cập nhật…

Khớp với kết quả khủng long tìm kiếm: to open science. Yang, S., Wei, W., & Zhao, Q. (2020). B7-H3, a checkpoint molecule, as a target for cancer immunotherapy. International Journal of Biological Sciences, 16 (11), 1767–1773. doi:10.7150/ijbs.41105. 10.7150/ijbs.41105. downloaded on 2020-05-05….

Tác giả: khủng long pubmed.ncbi.nlm.nih.gov

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Tóm tắt: khủng long The recent impressive clinical responses to antibody-based immunotherapy have prompted the identification of clinically relevant tumor antigens that can serve as targets in solid tumors. Among them, B7-H3, a member of the B7 ligand family, represents an attractive target for antibody-based immunothe …

Khớp với kết quả khủng long tìm kiếm: Among them, B7-H3, a member of the B7 ligand family, represents an attractive target for antibody-based immunotherapy, it is overexpressed on differentiated malignant cells and cancer-initiating cells, with limited heterogeneity, and high frequency (60% of 25,000 tumor samples) in many different cancer types, but has a limited expression at low level in normal tissues. In ……

Tác giả: khủng long www.ncbi.nlm.nih.gov

Ngày đăng khủng long : 20/1/2021

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Tóm tắt: khủng long Immunotherapy aiming at suppressing tumor development by relying on modifying or strengthening the immune system prevails among cancer treatments and points out a new direction for cancer therapy. B7 homolog 3 protein (B7-H3, also known as CD276), a newly …

Khớp với kết quả khủng long tìm kiếm: 19.07.2021 · B7 homolog 3 protein (B7-H3, also known as CD276), a newly identified immunoregulatory protein member of the B7 family, is an attractive and promising target for cancer immunotherapy because it is overexpressed in tumor tissues while showing limited expression in normal tissues and participating in tumor microenvironment (TME) shaping and development. ……

Tác giả: khủng long zgykdxxb.cpu.edu.cn

Ngày đăng khủng long : 26/3/2021

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Tóm tắt: khủng long Bài viết về Design and antitumor activity of immune checkpoint B7-H3 epitope …. Đang cập nhật…

Khớp với kết quả khủng long tìm kiếm: B7-H3 is an immune checkpoint molecule overexpressed on the surface of a variety of tumors, and is is an ideal target for tumor immunotherapy. In this study, nitrolated T cell epitope designed in the early stage of the laboratory was used to construct an epitope vaccine that can target immune checkpoint B7-H3. The vaccine can significantly inhibit tumor growth in the CT26 colon ……

Tác giả: khủng long link.springer.com

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Tóm tắt: khủng long Immune checkpoint inhibitors (ICIs) for programmed death-1 (PD-1) and programmed cell death-ligand 1 (PD-L1) have become preferred treatment strategies for several advanced cancers. However, response rates for these treatments are limited, which encourages the search for new ICI candidates. Recent reports have underscored significant roles of B7 homolog 3 protein (B7-H3) in tumor immunity and disease progression. While its multifaceted roles are being elucidated, B7-H3 has already entered clinical trials as a therapeutic target. In this review, we overview the recent results of clinical trials evaluating the antitumor activity and safety of B7-H3 targeting drugs. On this basis, we also discuss the challenges and opportunities arising from the application of these drugs. Finally, we point out current gaps to address in the understanding of B7-H3 function and regulation in order to fully unleash the future clinical utility of B7-H3-based therapies for the treatment of cancer.

Khớp với kết quả khủng long tìm kiếm: 05.11.2021 · Targeting B7-H3 represents a promising therapeutic strategy at the dawn of the second revolution of cancer immunotherapy revolution. B7-H3 is highly expressed by several pediatric and adult cancers including cancers refractory to PD-1/PD-L1 therapies. Therefore, B7-H3 appears as a suitable tumor-associated antigen for the development of antibody-based ……

Tác giả: khủng long www.frontiersin.org

Ngày đăng khủng long : 25/7/2021

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Tóm tắt: khủng long Immunotherapy aiming at suppressing tumor development by relying on modifying or strengthening the immune system prevails among cancer treatments and points out a new direction for cancer therapy. B7 homolog 3 protein (B7-H3, also known as CD276), a newly identified immunoregulatory protein member of the B7 family, is an attractive and promising target for cancer immunotherapy because it is overexpressed in tumor tissues while showing limited expression in normal tissues and participating in tumor microenvironment (TME) shaping and development. Thus far, numerous B7-H3-based immunotherapy strategies have demonstrated potent antitumor activity and acceptable safety profiles in preclinical models. Herein, we present the expression and biological function of B7-H3 in distinct cancer and normal cells, as well as B7-H3-mediated signal pathways in cancer cells and B7-H3-based tumor immunotherapy strategies. This review provides a comprehensive overview that encompasses B7-H3’s role in TME to its potential as a target in cancer immunotherapy.

Khớp với kết quả khủng long tìm kiếm: B7 homolog 3 protein (B7-H3, also known as CD276), a newly identified immunoregulatory protein member of the B7 family, is an attractive and promising target for cancer immunotherapy because it is overexpressed in tumor tissues while showing limited expression in normal tissues and participating in tumor microenvironment (TME) shaping and development. Thus far, numerous B7 ……

Tác giả: khủng long aacrjournals.org

Ngày đăng khủng long : 27/2/2021

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Tóm tắt: khủng long Abstract. B7-H3 (CD276) is an important immune checkpoint member of the B7 and CD28 families. Induced on antigen-presenting cells, B7-H3 plays an important role in the inhibition of T-cell function. Importantly, B7-H3 is highly overexpressed on a wide range of human solid cancers and often correlates with both negative prognosis and poor clinical outcome in patients. Challenges remain to identify the receptor(s) of B7-H3 and thus better elucidate the role of the B7-H3 pathway in immune responses and tumor evasion. With a preferential expression on tumor cells, B7-H3 is an attractive target for cancer immunotherapy. Based on the clinical success of inhibitory immune checkpoint blockade (CTLA-4, PD-1, and PD-L1), mAbs against B7-H3 appear to be a promising therapeutic strategy worthy of development. An unconventional mAb against B7-H3 with antibody-dependent cell-mediated cytotoxicity is currently being evaluated in a phase I clinical trial and has shown encouraging preliminary results. Additional therapeutic approaches in targeting B7-H3, such as blocking mAbs, bispecific mAbs, chimeric antigen receptor T cells, small-molecule inhibitors, and combination therapies, should be evaluated, as these technologies have already shown positive results in various cancer settings. A better understanding of the B7-H3 pathway in humans will surely help to further optimize associated cancer immunotherapies. Clin Cancer Res; 22(14); 3425–31. ©2016 AACR.

Khớp với kết quả khủng long tìm kiếm: 14.07.2016 · Human cancer immunotherapy strategies targeting B7-H3 A, blockade of B7-H3 with blocking mAbs neutralizes inhibitory signaling in its unidentified receptor(s) in T cells, NK cells, and other immune cells enabling effector function. B, B7-H3–specific ADCC initiated by Fc receptor engagement of NK cells and other immune cells induces death of tumor cells. ADCs bind to B7 ……

Tác giả: khủng long www.abbviescience.com

Ngày đăng khủng long : 7/3/2021

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Tóm tắt: khủng long B7-H3.

Khớp với kết quả khủng long tìm kiếm: B7-H3 (CD276) is an immune checkpoint member of the B7 and CD28 families. 2; B7-H3 was initially characterized as a T cell-stimulating protein, although the majority of current studies describe B7-H3 as a T cell inhibitor that promotes tumor aggressiveness and proliferation. This suggests that B7-H3 may be an important immunological target in cancer. 3…

Tác giả: khủng long www.einsteinmed.edu

Ngày đăng khủng long : 2/1/2021

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Tóm tắt: khủng long Bài viết về Molecular Pathways: Targeting B7-H3 (CD276) for Human Cancer …. Đang cập nhật…

Khớp với kết quả khủng long tìm kiếm: tumor cells, B7-H3 is an attractive target for cancer immuno-therapy. Based on the clinical success of inhibitory immune checkpoint blockade (CTLA-4, PD-1, and PD-L1), mAbs against B7-H3 appear to be a promising therapeutic strategy worthy of development. An unconventional mAb against B7-H3 with antibody-dependent cell-mediated cytotoxicity is currently…

Tác giả: khủng long www.semanticscholar.org

Ngày đăng khủng long : 28/5/2021

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Tóm tắt: khủng long Figure 1. Human cancer immunotherapy strategies targeting B7-H3 A, blockade of B7-H3 with blocking mAbs neutralizes inhibitory signaling in its unidentified receptor(s) in T cells, NK cells, and other immune cells enabling effector function. B, B7-H3–specific ADCC initiated by Fc receptor engagement of NK cells and other immune cells induces death of tumor cells. ADCs bind toB7-H3 expressed by tumor cells and are internalized andgenerate cytotoxicity to tumor cells. C, CD3/B7-H3– bispecific antibodies bind to tumor-expressed B7-H3 and crosslink the CD3 portion of the TCR complex, activating T cells in the tumor microenvironment for tumor cell death. D, small-molecule inhibitors may bind to specific regions of B7-H3, such as the FG loop of the IgV domain, inhibiting the ligand–receptor interaction between tumor cells and immune cells, thus blocking receptor signaling and restoring effector function of immune cells. E, engineered CAR T cells recognize membrane B7-H3 and directly kill tumor cells. F, blocking mAbs against B7-H3 in combination with radiation, chemotherapy, targeted therapy, or other immune checkpoint inhibitors synergize to generate more effective antitumor immune responses. – “Molecular Pathways: Targeting B7-H3 (CD276) for Human Cancer Immunotherapy”

Khớp với kết quả khủng long tìm kiếm: 20.05.2016 · Clinical Cancer Research. B7-H3 (CD276) is an important immune checkpoint member of the B7 and CD28 families. Induced on antigen-presenting cells, B7-H3 plays an important role in the inhibition of T-cell function. Importantly, B7-H3 is highly overexpressed on a wide range of human solid cancers and often correlates with both negative prognosis and ……

Tác giả: khủng long www.frontiersin.org

Ngày đăng khủng long : 7/7/2021

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Tóm tắt: khủng long Chimeric antigen receptor (CAR)-modified natural killer (NK) cell therapy represents a kind of promising anti-cancer treatment because CAR renders NK cells activation and recognition specificity toward tumor cells. An immune checkpoint molecule, B7-H3, plays an inhibitory role in modulation of NK cells. To enhance NK cell functions, we generated NK-92MI cells carrying anti-B7-H3 CAR by lentiviral transduction. The expression of anti-B7-H3 CAR significantly enhanced the cytotoxicity of NK-92MI cells against B7-H3-positive tumor cells. In accordance with enhanced cytotoxicity, the secretions of perforin/granzyme B and expression of CD107a were highly elevated in anti-B7-H3 CAR-NK-92MI cells. Moreover, compared to unmodified NK-92MI cells, anti-B7-H3 CAR-NK-92MI cells effectively limited tumor growth in mouse xenografts of non-small cell lung cancer and significantly prolonged the survival days of mice. This study provides the rationale and feasibility of B7-H3-specific CAR-NK cells for application in adoptive cancer immunotherapy.

Khớp với kết quả khủng long tìm kiếm: An immune checkpoint molecule, B7-H3, plays an inhibitory role in modulation of NK cells. To enhance NK cell functions, we generated NK-92MI cells carrying anti-B7-H3 CAR by lentiviral transduction. The expression of anti-B7-H3 CAR significantly enhanced the cytotoxicity of NK-92MI cells against B7-H3-positive tumor cells. In accordance with enhanced cytotoxicity, the ……

Tác giả: khủng long www.dovepress.com

Ngày đăng khủng long : 25/1/2021

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Tóm tắt: khủng long Agents targeting the B7 family co-inhibitory receptors cytotoxic T-lymphocyte antigen-4 and programmed cell death protein-1, or its ligand have a pivotal role.

Khớp với kết quả khủng long tìm kiếm: 22.06.2021 · We hereby present the main evidence on the value of VISTA as an immune checkpoint in solid and hematological malignancies. We also review its value as a potential target for cancer immunotherapy, by reporting the results of Phase I and II clinical trials assessing the use of drugs targeting VISTA. The complexity of its pathway, along with some unclear biological aspects ……