I 20 migliori 5ht2a schizophrenia del 2022

Autore: pubmed.ncbi.nlm.nih.gov

Data di scrittura: 23/2/2021

Valutazione: 2 ⭐ ( 29800 voti )

Più votati: 5 ⭐

Valutazione più bassa: 4 ⭐

Descrizione: The correlation between the clinical activity of antipsychotic agents and their affinity for the D2 dopamine receptor has been the mainstay of the hypothesis that schizophrenia is due to excessive dopaminergic function. More recently, the unique clinical profile of the atypical antipsychotic clozapi …

Corrisponde al risultato della ricerca: … and their affinity for the D2 dopamine receptor has been the mainstay of the hypothesis that schizophrenia is due to excessive dopaminergic function…. guarda ora

Autore: www.ncbi.nlm.nih.gov

Data di scrittura: 16/3/2021

Valutazione: 1 ⭐ ( 3519 voti )

Più votati: 5 ⭐

Valutazione più bassa: 1 ⭐

Descrizione: Il contenuto dell’articolo ruota intorno Serotonin 2A (5-HT2A) Receptor Function: Ligand-Dependent Mechanisms and Pathways – Serotonin Receptors in Neurobiology – NCBI Bookshelf. In aggiornamento…

Corrisponde al risultato della ricerca: by I Raote · 2007 · Cited by 70 Schizophrenia: 5-HT2A is thought to play a significant role in this disorder. This is partly due to the fact that most typical and almost all atypical …… guarda ora

Autore: www.frontiersin.org

Data di scrittura: 26/5/2021

Valutazione: 1 ⭐ ( 34969 voti )

Più votati: 5 ⭐

Valutazione più bassa: 5 ⭐

Descrizione: Serotonin 5-HT2A receptors (5-HT2ARs) are widely distributed in the central nervous system, especially in brain region essential for learning and cognition. In addition to endogenous 5-HT, several hallucinogens, antipsychotics, and antidepressants function by targeting 5-HT2ARs. Preclinical studies show that 5-HT2AR antagonists have antipsychotic and antidepressant properties, whereas agonist ligands possess cognition-enhancing and hallucinogenic properties. Abnormal 5-HT2AR activity is associated with a number of psychiatric disorders and conditions, including depression, schizophrenia, and drug addiction. In addition to its traditional activity as a G protein-coupled receptor (GPCR), recent studies have defined novel operations of 5-HT2ARs. Here we review progress in the (1) receptor anatomy and biology: distribution, signaling, polymerization and allosteric modulation; and (2) receptor functions: learning and memory, hallucination and spatial cognition, and mental disorders. Based on the recent progress in basic research on the 5-HT2AR, it appears that post-training 5-HT2AR activation enhances non-spatial memory consolidation, while pre-training 5-HT2AR activation facilitates fear extinction. Further, the potential influence that 5-HT2AR-elicited visual hallucinations may have on visual cue (i.e., landmark) guided spatial cognition is discussed. We conclude that the development of selective 5-HT2AR modulators to target distinct signaling pathways and neural circuits rep…

Corrisponde al risultato della ricerca: by G Zhang · 2015 · Cited by 188 Abnormal 5-HT2AR activity is associated with a number of psychiatric disorders and conditions, including depression, schizophrenia, and drug …‎Abstract · ‎Introduction · ‎5-HT2AR Anatomy and… · ‎5-HT2AR Functions in CNS… guarda ora

Autore: www.nature.com

Data di scrittura: 15/7/2021

Valutazione: 5 ⭐ ( 76526 voti )

Più votati: 5 ⭐

Valutazione più bassa: 1 ⭐

Descrizione: Il contenuto dell’articolo ruota intorno Opposite alterations of 5HT2A receptor brain density in subjects with schizophrenia: relevance of radiotracers pharmacological profile | Translational Psychiatry. In aggiornamento…

Corrisponde al risultato della ricerca: by R Diez-Alarcia · 2021 · Cited by 1 This study investigates 5HT2AR density in the post-mortem prefrontal cortex from subjects with schizophrenia and controls using three …… guarda ora

Autore: www.nature.com

Data di scrittura: 18/7/2021

Valutazione: 2 ⭐ ( 82006 voti )

Più votati: 5 ⭐

Valutazione più bassa: 5 ⭐

Descrizione: null

Corrisponde al risultato della ricerca: by HY Meltzer · 1999 · Cited by 933 The potent D4/5-HT2a receptor antagonist fananserin has been found ineffective in acutely psychotic patients with schizophrenia (Truffinet et al. in press), …

Autore: link.springer.com

Data di scrittura: 21/3/2021

Valutazione: 5 ⭐ ( 29871 voti )

Più votati: 5 ⭐

Valutazione più bassa: 5 ⭐

Descrizione: Serotonin (5-HT) was once thought to have a role in visual hallucinations based on the findings that lysergic acid diethylamide was found to be a serotonin agonist. This led to a search for endogenous indole hallucinogens in schizophrenia, which ultimately proved unsuccessful. Studies of 5-HT receptor subtypes opened up the issue in several ways, with the 5-HT2A, 5-HT2C, and 5-HT1A receptors seeming to be of greatest importance, and 5-HT6 and 5-HT7 receptors of secondary importance. Linkages between 5-HT, dopamine (DA), glutamate, acetylcholine, and brain-derived neurotrophic factor, have provided some important leads as to how 5-HT may be involved in schizophrenia. It has been found that 5-HT2A rather than 5-HT2C receptor stimulation is the most likely basis for the hallucinogenic effects of lysergic acid diethylamide, but recent neurochemical and genetic studies have raised the possibility that the 5-HT2C receptor may also be important in psychosis based on its ability to regulate tonic dopaminergic function. The discovery that 5-HT2A receptor blockade was an important component of the action of clozapine and other atypical antipsychotic drugs also restored interest in a primary role of 5-HT2A receptors in the etiology of psychosis. 5-HT1A receptors also have been found to enhance DA release in the cortex and hippocampus and are primary factor in the regulation of DA release in both of these regions. Postmortem studies have found some evidence of non-drug-induced increased density of 5-HT1A receptors. Genetic studies are ongoing to link single nucleotide polymorphisms of the 5-HT2A, 5-HT2C, and 5-HT1A receptors to some schizophrenia phenotypes. It is likely that serotonergic function will become even more important in developing genetic and other markers for schizophrenia novel therapies, particularly for psychosis and cognition.

Corrisponde al risultato della ricerca: by HY Meltzer · 2006 · Cited by 6 Abdolmaleky HM, Faraone SV, Glatt SJ, Tsuang MT:Meta-analysis of association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia…. guarda ora

Autore: www.sciencedirect.com

Data di scrittura: 15/7/2021

Valutazione: 2 ⭐ ( 18966 voti )

Più votati: 5 ⭐

Valutazione più bassa: 2 ⭐

Descrizione: Serotonin 5-HT2A receptors (5-HT2ARs) have been implicated in schizophrenia. However, postmortem studies on 5-HT2ARs expression and functionality in s…

Corrisponde al risultato della ricerca: by A García-Bea · 2019 · Cited by 16 Overall, the data suggest a supersensitive 5-HT2AR signaling through inhibitory Gαi1-proteins in schizophrenia. Together with previous results, a dysfunctional …… guarda ora

Autore: www.futuremedicine.com

Data di scrittura: 7/4/2021

Valutazione: 1 ⭐ ( 65555 voti )

Più votati: 5 ⭐

Valutazione più bassa: 2 ⭐

Descrizione: Il contenuto dell’articolo ruota intorno 5-HT2A receptors and Parkinson’s disease psychosis: a pharmacological discussion | Neurodegenerative Disease Management. In aggiornamento…

Corrisponde al risultato della ricerca: by P Huot · 2018 · Cited by 2 Blockade of the serotonin 2A (5-HT2A) receptor is an approach that was shown to be effective at alleviating Parkinson’s disease psychosis, …… guarda ora

Autore: en.wikipedia.org

Data di scrittura: 10/8/2021

Valutazione: 1 ⭐ ( 56939 voti )

Più votati: 5 ⭐

Valutazione più bassa: 4 ⭐

Descrizione: Il contenuto dell’articolo ruota intorno 5-HT2A receptor – Wikipedia. In aggiornamento…

Corrisponde al risultato della ricerca: Studies have demonstrated a relationship between EGR3 and HTR2A, and schizophrenia like behaviors in transgenic animals. Exactly how these results translate …… guarda ora

Autore: www.mdpi.com

Data di scrittura: 28/7/2021

Valutazione: 3 ⭐ ( 72106 voti )

Più votati: 5 ⭐

Valutazione più bassa: 1 ⭐

Descrizione: null

Corrisponde al risultato della ricerca: Aug 20, 2018 Moreover, antipsychotics prescribed to treat schizophrenia are used in … entities, in particular adenosine A2A–D2 and serotonin 5HT2A–D2 …

Autore: www.cambridge.org

Data di scrittura: 30/4/2021

Valutazione: 2 ⭐ ( 94631 voti )

Più votati: 5 ⭐

Valutazione più bassa: 3 ⭐

Descrizione: 5-HT2A receptor blockade in patients with schizophrenia treated with risperidone or clozapine – Volume 173 Issue 3

Corrisponde al risultato della ricerca: by MJ Travis · 1998 · Cited by 98 5-HT2A receptor blockade in patients with schizophrenia treated with risperidone or clozapine. A SPET study using the novel 5-HT2A ligand 1231-5-1-R-91150…. guarda ora

Autore: www.scielo.br

Data di scrittura: 12/2/2021

Valutazione: 1 ⭐ ( 48255 voti )

Più votati: 5 ⭐

Valutazione più bassa: 4 ⭐

Descrizione: Data from epidemiological studies have demonstrated that genetics is an important risk factor…

Corrisponde al risultato della ricerca: by V Bertola · 2007 · Cited by 11 serotonin; genetic association; allele; genotype; 5HT2A; schizophrenia … between the C516T polymorphism in the 5-HT2A receptor gene and schizophrenia…. guarda ora

Autore: psycnet.apa.org

Data di scrittura: 13/1/2021

Valutazione: 3 ⭐ ( 64734 voti )

Più votati: 5 ⭐

Valutazione più bassa: 4 ⭐

Descrizione: Il contenuto dell’articolo ruota intorno APA PsycNet. In aggiornamento…

Corrisponde al risultato della ricerca: by FX Vollenweider · 1998 · Cited by 750 Explored the roles of serotonin2A (5-hydroxytryptamine2A [5-HT2A]) and/or dopamine (DA) D2 receptors in psychological effects of indoleamine hallucinogens …

Autore: www.hindawi.com

Data di scrittura: 23/7/2021

Valutazione: 5 ⭐ ( 34093 voti )

Più votati: 5 ⭐

Valutazione più bassa: 1 ⭐

Descrizione: The serotonin receptor gene (5-HT2A) has been reported to be a susceptible factor in behavioral and psychological symptoms of dementia (BPSD) in Alzheimer’s disease (AD). However, previous results were conflicting. We aim to investigate the association of 5-HT2A T102C with BPSD in AD using a meta-analysis. Studies were collected using PubMed, Web of Science, the Cochrane Library databases, Chinese National Knowledge Infrastructure (CNKI), and Embase. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess associations. Nine studies with 1899 AD patients with/without BPSD were included in this meta-analysis. The 102C and CC genotypes were associated with psychosis in AD (102C:

, OR [95% CI] = 3.19 [2.12–4.79]; CC:

, OR [95% CI] = 7.24 [3.60–14.59]). The TT genotype was significantly associated with hallucinations, aberrant motor behavior, and psychosis in AD (hallucinations:

, OR [95% CI] = 0.52 [0.36–0.77]; aberrant motor behavior:

, OR [95% CI] = 0.58 [0.35–0.95]; and psychosis:

, OR [95% CI] = 0.34 [0.17–0.67]). No association was observed between T102C alleles or genotypes and delusions, agitation/aggression, depression, and apathy (

). Thus, the 5HT2A T102C might be a susceptible factor for hallucinations, aberrant motor behavior, and psychosis in AD. The potential mechanism of this polymorphism in BPSD in AD requires further exploration.

Corrisponde al risultato della ricerca: by L Tang · Cited by 14 The TT genotype was significantly associated with hallucinations, aberrant motor behavior, and psychosis in AD (hallucinations: , OR [95% CI] = 0.52 [0.36–0.77]; …… guarda ora

Autore: oamjms.eu

Data di scrittura: 12/1/2021

Valutazione: 5 ⭐ ( 44037 voti )

Più votati: 5 ⭐

Valutazione più bassa: 2 ⭐

Descrizione: Il contenuto dell’articolo ruota intorno Potential Link between T102C Polymorphism in the Serotonin Receptors (5-HT2A) Gene and Treatment Response of Risperidone on Schizophrenia | Open Access Macedonian Journal of Medical Sciences. In aggiornamento…

Corrisponde al risultato della ricerca: by S Syamsuddin · 2021 Schizophrenia, Gene polymorphism, Serotonin receptors gene, 5HT2A, T102C, … BACKGROUND: Schizophrenia affects 1% of population and its …… guarda ora

Autore: psychopharmacologyinstitute.com

Data di scrittura: 14/5/2021

Valutazione: 2 ⭐ ( 57802 voti )

Più votati: 5 ⭐

Valutazione più bassa: 5 ⭐

Descrizione: Il contenuto dell’articolo ruota intorno Psychopharmacology Institute. In aggiornamento…

Corrisponde al risultato della ricerca: This presentation discusses the dopamine hypothesis of schizophrenia and the … properties of second generation agents, such as: 5HT2A antagonism, …Jul 13, 2016 · Uploaded by Psychopharmacology Institute

Autore: casereports.bmj.com

Data di scrittura: 29/8/2021

Valutazione: 2 ⭐ ( 65080 voti )

Più votati: 5 ⭐

Valutazione più bassa: 3 ⭐

Descrizione: null

Corrisponde al risultato della ricerca: Jun 27, 2018 schizophrenia with intractable hallucinations despite state of the art care, … hallucinations, suggesting a possible role of the 5Ht2a.

Autore: go.drugbank.com

Data di scrittura: 14/7/2021

Valutazione: 5 ⭐ ( 2290 voti )

Più votati: 5 ⭐

Valutazione più bassa: 1 ⭐

Descrizione: Il contenuto dell’articolo ruota intorno Serotonin 5-HT2A Receptor Antagonists | DrugBank Online. In aggiornamento…

Corrisponde al risultato della ricerca: DrugTargetTypeMethysergide5‑hydroxytryptamine receptor 2AtargetMethysergide5‑hydroxytryptamine receptor 1AtargetMethysergide5‑hydroxytryptamine receptor 7targetView 945 more rows

Autore: grantome.com

Data di scrittura: 18/2/2021

Valutazione: 3 ⭐ ( 1808 voti )

Più votati: 5 ⭐

Valutazione più bassa: 3 ⭐

Descrizione: One of the guiding objectives of modern schizophrenia research is to build a bridge from molecular and cellular biology to the clinical symptoms of this psychotic mental disorder. Monoaminergic neurot…

Corrisponde al risultato della ricerca: One of the guiding objectives of modern schizophrenia research is to build a bridge from molecular and cellular biology to the clinical symptoms of this …… guarda ora

Autore: grantome.com

Data di scrittura: 26/8/2021

Valutazione: 1 ⭐ ( 33083 voti )

Più votati: 5 ⭐

Valutazione più bassa: 4 ⭐

Descrizione: Our final goal is to mechanistically characterize the essential role of the serotonin 5-HT2A (5HT2A) receptor and the metabotropic glutamate 2 (mGlu2) receptor as a G protein-coupled receptor (GPCR) h…

Corrisponde al risultato della ricerca: The neurotransmitters serotonin and glutamate both have been the target of considerable attention regarding psychosis and antipsychotic drug development. Family …… guarda ora